Skip to main content

Ursolic acid: properties, benefits, sources


Ursolic Acid Review, Benefits and possible Side Effects. To expose the properties and benefits that ursolic acid has mainly on the skeletal muscles and the creation of brown fat, I will take as a basis a study conducted in men titled: "Ursolic acid increases the amount of the irisine hormone in the blood Which increases muscle strength during resistance exercises. "

Ursolic Acid Review - Health Benefits For Skeltal Muscle Growth? So, to understand this study and why ursolic acid is good for your health and well-being, and to explain how ursolic acid can increase muscle strength during resistance training, you should first clarify some concepts mentioned in the title of this study:

NOTE: ursolic acid can be found in tablets, powders and capsules but also in fruits such as apple, pear, grapes, among others and in many vegetables, mainly in their shells. So wash very well before eating them ... and chew very well the husks before swallowing them in order to promote a better digestion and absorption of ursolic acid... ursolic acid could inhibit muscle atrophy.

1. Irisine: irisine is a hormone that tends to increase its levels while a person performs exercise, especially when it comes to exercises of high intensity ... or also performed at moderate intensity but long duration (resistance), and it is responsible Of causing our body to produce heat and at the same time is able to help us turn our white fat into brown fat (brown adipose tissue)... So Ursolic acid promotes its creation by increasing the amount of irisine.

2. Brown fat or brown adipose tissue: thanks to the exercise and consumption of foods and / or supplements containing ursolic acid, our body is able to increase the production of this type of fat and reduce the levels of White fat that serves as reservoir of energy (which usually makes you look fat) ...

... instead, brown fat that accumulates in brown adipose tissue allows us to generate heat, is a type of tissue that is more vascularized (it gets more blood) and has a greater amount of mitochondria so we could say that we can burn more white fat thanks to this type of brown fabric and we can also protect us more against the cold (low temperatures).

 3. Resistance exercises: Usually this type of exercises have as main objective to increase the anabolic capacities of our organism through hormonal and molecular factors, contributing to the increased secretion of the hormone insulin, increasing also the production of Insulin Growth Factor (IGF-1) And also myoquines, all these being hormones that contribute to the processes of growth and muscular development, mainly.

Resistance exercises act primarily on the elevation of IGF-1 which is a hormone that can regulate hypertrophy and muscle strength, and is also closely associated with myoquine levels in the bloodstream.

Ursolic acid influences muscle recovery, increased muscle mass and increased brown fat (brown adipose tissue)

Ursolic acid: properties, benefits, sources
Method of study: The participants of the study whose title I mentioned in the first paragraph of this article, performed a resistance exercise program under strict supervision ... There was one group to which it was supplemented with ursolic acid for 8 weeks, there was a control group who was given a placebo. None of the groups were mentioned to which group they belonged.

  Blood samples were taken in both groups before and after 8 weeks of training, and there was also a prior and subsequent evaluation of both body composition and muscle strength in each individual in each group.

Subjects: 30 healthy Korean men who were performing resistance exercises for an average period of 3 years were chosen as the first instance for this study, of which only 16 remained according to the inclusion and exclusion criteria of the study. The average decimal age of participants was 29.7 years.

Intervention: Participants performed the resistance exercise program for 8 weeks using free weights and machines under the supervision of a trained instructor who led the stretching exercises as a warm-up phase to prevent soft tissue injuries and ensure the safety of each subject.

Ursolic acid supplementation: The placebo group received 3 capsules daily containing 450 mg of guar gum and the Ursolic Acid group received 3 capsules daily containing 450 mg rosemary ursolic acid extract.

The capsules had the same color, shape and size, and participants took 1 capsule (150 mg) after each of the 3 main meals. Participants were followed up by questionnaire by e-mail, cell phone and visits to the laboratory to confirm compliance with the supplementation throughout the study.

Results of the study: no significant differences were observed in body composition and strength parameters between the group to be supplemented with ursolic acid and the placebo group before applying the 8 weeks of resistance training.

After 8 weeks of training, the group that consumed ursolic acid had a significant reduction in white fat levels compared to the group that consumed placebo. Although the increase in lean mass (lean muscle mass) showed only a slightly significant increase in the ursolic acid group compared to the placebo group.

As for the levels of the Irisine and IGF-1 hormones, and the strength characteristic, all three of these variables showed significant increases in their post values ​​with respect to their pre values ​​in the group consuming ursolic acid compared to the group that only consumed placebo.

Conclusion: until now the simplest conclusion would be that ursolic acid helps the production of brown fat, the elimination of white fat and the increase of the hormones Irisin and IGF-1 which contribute to the aforementioned brown fat muscle hypertrophy and strenght.

Second study on ursolic acid, although this time will be tested in rats


Ursolic acid: properties, benefits, sources
I will now take as reference a study in rats which is titled: "Ursolic acid increases skeletal muscle mass and brown fat, and decreases the risks of obesity caused by poor eating habits, glucose intolerance and fatty liver" .

Well, actually the title of this study that I'm going to reference is not so long, but I wanted to do it more specific ... the real title I will mention it in the next subtitle. The goal of this study will then be to expose the benefits of ursolic acid on the skeletal muscles and the creation of brown fat or also known as brown adipose tissue.

As an initial part, it should be noted that ursolic acid is found mainly in the shell of fruits such as apples, grapes, pear, among others. However, it is worth noting that it is good to wash these very well before ingesting them especially when it comes to countries that are not developed where the health regulations are questionable.

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease


NOTE: This study aimed to study rats and mice. Even so the results in humans can also occur, but it must be taken into account that all work must not be left to ursolic acid since other eating and life habits play an important role to prevent muscle atrophy and promote muscle hypertrophy and also to prevent several diseases.

INTRODUCTION
Ursolic acid is a lipophilic pentacyclic triterpenoid that contributes to "waxy coats" in apples, other fruits and many herbs, including some medicinal folk herbal for diabetes. We have recently identified ursolic acid in a screen for small molecule inhibitors of skeletal muscle atrophy.

In that study, we assessed the effects of fasting and spinal cord injury on mRNA levels of skeletal muscle in humans, and used that information to generate signatures of mRNA expression unbiased for human skeletal muscle atrophy. These signatures were then used to consult the connectivity map for compounds whose expression signatures negatively correlated with signatures of human muscle atrophy. Of 1300 compounds in the connectivity map, ursolic acid emerged as the most likely inhibitor of muscle atrophy.

To test the hypothesis that ursolic acid could inhibit muscle atrophy, we studied mice that had been fasted or subjected to denervation of the surgical muscle, and found that ursolic acid reduced muscle atrophy. Then investigated the effect of ursolic acid in the absence of a stimulus of atrophy by adding ursolic acid to standard food mice for 5 weeks. In that context, ursolic acid would induce hypertrophy in the skeletal muscles.

Since Akt protein kinase (also known as PKB) inhibits muscle atrophy and promotes muscle hypertrophy, we examined the effect of ursolic acid on Akt. Ursolic acid was found to increase Akt activity in mouse skeletal muscle and C2C12 cultures in skeletal myotubes. In urinary myotubes, ursolic acid increased Akt activity at least in part by enhancing insulin-dependent receptor-binding and insulin-like growth factor receptor 1 (IGF-1) activation.

In addition to causing muscle hypertrophy, genetic interventions that activate Akt (PKB) specifically in skeletal muscle also increase energy expenditure, reduce adiposity and blood glucose, and impart resistance to obesity induced by diet, glucose intolerance and Fatty liver disease.

Similarly, ursolic acid was found to reduce adiposity and blood glucose in non-obese mice, and others found that ursolic acid reduced total body weight, white fat, glucose intolerance, and hepatic steatosis in Mice with high fat content.

Based on these considerations, the hypothesis is that ursolic acid could increase Akt skeletal muscle activity in a diet-induced obesity model of mice, leading to muscle hypertrophy, increased energy expenditure, and Both, reduced obesity, impaired glucose tolerance and fatty liver disease ... In the present study, this hypothesis has been tested, and it was found that ursolic acid increases not only the skeletal muscle, but also another tissue that opposes diet-induced obesity: brown fat.

References:

First study: Yung Seo, D. et al. (2014). Ursolic Acid-Induced Elevation of Serum Irisin Augments Muscle Strength During Resistance Training in Men. Https://synapse.koreamed.org/DOIx.php?id=10.4196/kjpp.2014.18.5.441

Second study: Steven D. Kunkel et. to the. (2012). Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease. Http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039332

Comments

Popular Posts

Crossfit and steroids - crossfitters use steroids?

Do crossfit athletes use anabolic steroids? Have you ever wondered if athletes competing in crossfit international events consume or inject artificial anabolic steroids? By these "Roids" I mean testosterone types that are manufactured in laboratories (oxandrolone, Clenbuterol Anavar, Winstrol, Dianabol, Deca Durabolin, Primobolan, Anadrol, Sustanon 250, testosterone cypionate, Testosterone Enanthate, among others known and unknown "roids").

I emphasize that I am talking about competitions of great popularity and not about the crossfitters competing at amateur level, because perhaps these do use some type of prohibited substances: anabolic artificial steroid or growth hormone, and only these athletes and perhaps their trainers know this fact, since I doubt that there is an anti-doping control (or at least not a rigorous one) for fewer level competitions.... Does the Fittest Man or woman on Earth Dope?

Cycle of steroids for crossfit? Please, this is only for cowards,…

Weight training workout routine for ectomorph, skinny or thin men

This is an Ectomorph routine. This weight training workout routine is mainly for those men with ectomorph somatotype who want to build muscle (muscle hypertrophy). Generally thin or ectomorphic men are those who have a difficulty to gain weight either in fat and/or Lean mass (muscle mass), due to genetics, no matter how much they eat, no matter how many protein supplements they ingest, it is difficult for them to increase the body size or body mass no matter if is fat or skeletal muscle mass. Men who often train hard but do not see decent results (low muscle hypertrophy), so here I will explain how they should train to achieve the goals and increase muscle size.

This routine is special for Ectomorphs, hose men who can give themselves the "good life" by eating any type of food in large quantities, and still remain thin. Many people will think that this is some kind of "blessing", but other people think it is the opposite beacuse they want to look "bigger"…

How to Increase Human Growth Hormone (HGH) Naturally

How can I boost human growth hormone naturally in my body? Is it possible to raise the production of human growth hormone without consuming drugs? These are questions many people ask because it is an important hormone produced by the pituitary gland which plays a key role in growth (tissues and therefore height), body composition (increase of muscle mass by increasing the Protein synthesis and reduction of body fat), cell repair and metabolism in general ... Here I will mention some tips that you can apply to increase the production of human growth hormone naturally in your body.

How to stimulate human growth hormone in adolescents and children? Growth hormone stimulates mainly the muscles so these can grow and for this main reason many men and women want to try almost any way to increase its natural production ... It also helps improve muscle strength and performance during exercise sessions, and also helps post-workout recovery, recovery after suffering some injury and / or illness.…

How to clean my penis to avoid fungal infections and bad odors?

What soap to use to clean my penis? In order to keep your penis clean, looking good and with a nice smell (well, its natural smell) your need to use a Syndet, which in some countries it is known as "the soap without soap" or as the better alternative to clean your body and penis without causing any alteration to the pH of this areas in order to avoid infections,

To clean the "trunk", glans, neck, corona, urethra and foreskin of your penis, it is recommended that you use a Syndet Soap or only known as Syndet. This "soap substitute" does not irritate or alter the pH of your penis or the rest of your body.

Conventional soaps that are usually relatively cheap and used for cleaning the rest of the body and often also the penis, whether they are used in bars or liquids, these, cheap, "regular" and conventional soaps are not recommended for you to clean your male member (also not recommended for vaginal cleaning) since its pH is usually either neutr…

Musclemeds Carnivor (Isolate and Mass): review and opinions

Is Carnivor good if I want to gain muscle mass? Does Carnivor taste like meat? These and other questions that are generated based on this protein supplement will be answered in this article, also of course I will expose my opinion already having taken this Protein for more than 6 months in its versions both Isolate and Mass ... NOTE: the Carnivor can be consumed by men and women.

The first thing I want to comment is the fact of its taste. Musclemeds Carnivor does not taste like meat, does not taste like any other salty food, does not taste bad. In fact it has a pleasant taste at least in its presentation with chocolate flavor. The most important thing is that it does not have a "gooey" flavor and does not generate that feeling of "fullness" that other Mass Gainer (or "clean" proteins) both types beef and whey proteins can generate.

In fact its flavor and its texture I find them quite pleasant, fairly easy to digest. Something curious that I want to comm…

Masturbation - Is masturbation good or bad for health?

Consequences on masturbation. Have you heard that masturbating is good for your health because it reduces the risk of prostate cancer? Have you been told that you need to masturbate every day because spermatozoa need to be renewed daily for better health? Have you been told that you should masturbate every day several times a day so that the quality of your semen improves?

Is it bad for health to masturbate daily? Some people may have read that stopping masturbating or in fact stopping ejaculation can be bad for your health as it can increase some health risks in men... In this article I will talk about some effects of masturbation on your body, mind and soul (well, perhaps not in your soul per se).

Is masturbating too much (everyday) injurious to health? Anthony Stella and Spring Cooper, two lecturers on sexual health at the University of Sydney in Australia, say that masturbation is good for men because it reduces the risk of prostate cancer because it improves the action of the Imm…

The Best Exercises to Build Muscle according to science

The best exercises to gain muscle mass according to science. The exercises that generate better results in terms of increasing or building muscle mass are those that collect more muscle fibers in each movement, and which also force safe and wide ranges of movement to generate a good stimulus that allows adequate hypertrophy without the risk of injury.

Best Muscle Building Exercises According to Science. Of course this safety in the range of joint movement is rooted on the flexibility that a person has or is acquiring, since flexibility is a quality that gives strength to a muscle and therefore allows you to perform exercises with higher loads to try to increase your muscle volume (muscle hypertrophy).

Best exercises for your workout program. And be aware these exercises are not like those those that usually upload empirical people on their profiles in instagram. These are very traditional exercises really, and at the same time safe exercises if you execute them well, without compromis…